David Regan graduated from the Manhattan School of Music in New York where he studied saxophone with Joe Allard. As a featured member of the college big band he performed with guest soloists Randy Brecker, Bob Mintzer, Woody Shaw and Phil Woods in concerts at 7th Avenue South and the Village Vanguard. He continued his studies on saxophone, flute and clarinet with George Coleman, Danny Bank and Herb Geller.​ ​​​​​​​​

David is a gifted musician and composer and has led his own groups in American and European jazz clubs. He has played with The Fusionaires, The Four Tops, The Temptations, Natalie Cole, The Tom Pierson Orchestra, Ray Barreto, Paquito D'Rivera, John Hollenbeck, Mario Bauzá, Bill Charlap and Ron Miles. His saxophone playing has also been featured in television and radio commercials for Migros, Swatch and Kuoni Travel. He has performed throughout Switzerland with Pepe Lienhard, the Dani Felber Orchestra, as the director of the Zurich Jazz Orchestra, and featured with the 21st Century Orchestra in Lucerne's KKL hall performing the film music of Michael Giachinno. 

The David Regan Orchestra, founded in 2001, often performs with internationally renowned jazz artists, including Scott Robinson, Dick Oatts, Bob Mintzer and Steve Wilson and is featured in Max Wirz's book BIG BANDS - EINST UND JETZT. 

Currently, David is busy with his own jazz quartet and The David Regan Orchestra. Additionally, he is a professor of music at the Zürich Hochschule der Künste (ZHdK) as director of the big band and is a private music teacher at the Zürich International School.